International Center for Polyamine Disorders

The International Center for Polyamine Disorders (ICPD) is a collaborative translational and clinical research program operated under the auspices of Michigan State University and Spectrum Health West Michigan in Grand Rapids, Michigan. The ICPD launched in summer 2020 and includes a polyaminopathy patient biobank, a state-of-the-art translational research lab core and a clinical genetics team at Spectrum Health West Michigan. The ICPD offers innovative ways to study polyaminopathies, associated disabilities and develop strategies for treatment and prevention. This collaborative effort between Spectrum Health and Michigan State University brings world leading experts in the field from the bench and clinic together to study these rare genetic diseases.

The ICPD is led by:

  • Caleb Bupp

    Caleb Bupp, MD, FACMG, Clinical Director ICPD, Section Chief – Medical Genetics and Genomics at Helen DeVos Children’s Hospital

  • Surender Rajasekaran

    Surender Rajasekaran, MD, Research Director ICPD, Medical Director of Research at Spectrum Health West Michigan

  • Andre Bachmann

    Andre Bachmann, PhD, Scientific Director ICPD, Professor, Associate Chair for Research in the Department of Pediatrics and Human Development and Michigan State University faculty

  • Charles Schwartz

    Charles E. Schwartz, PhD, former Director of Research, JC Self Research Institute, Greenwood Genetic Center and Adjunct Professor, Department of Pediatrics and Human Development, Michigan State University

References

  1. Bupp CP, Schultz CR, Uhl KL, Rajasekaran S, Bachmann AS. Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features. Am J Med Genet A. 2018;176(12):2548-2553. PMID: 30239107

  2. Bachmann AS, Geerts D. Polyamine Synthesis as a target of MYC oncogenes. J Biol Chem. 2018;293(48):18757-18769. PMID: 30404920

  3. Schultz CR, Bupp CP, Rajasekaran S, Bachmann AS. Biochemical features of primary cells from a pediatric patient with a gain-of-function ODC1 genetic mutation. Biochem J. 2019;476(14):2047-2057. PMID: 31249027

  4. Priotto G, Kasparian S, Mutombo W, Ngouama D, Ghorashian S, Arnold U, Ghabri S, Baudin E, Buard V, Kazadi-Kyanza S, Ilunga M, Mutangala W, Pohlig G, Schmid C, Karunakara U, Torreele E, Kande V. Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. Lancet. 2009;374(9683):56-64. PMID: 19559476

  5. Saulnier Sholler GL, Gerner EW, Bergendahl G, MacArthur RB, VanderWerff A, Ashikaga T, Bond JP, Ferguson W, Roberts W, Wada RK, Eslin D, Kraveka JM, Kaplan J, Mitchell D, Parikh NS, Neville K, Sender L, Higgins T, Kawakita M, Hiramatsu K, Moriya SS, Bachmann AS. A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma. PLoS One. 2015;10(5):e0127246. PMID: 26018967