International Center for Polyamine Disorders
The International Center for Polyamine Disorders (ICPD) is a collaborative translational and clinical research program operated under the auspices of Michigan State University and Spectrum Health West Michigan in Grand Rapids, Michigan. The ICPD launched in summer 2020 and includes a polyaminopathy patient biobank, a state-of-the-art translational research lab core and a clinical genetics team at Spectrum Health West Michigan. The ICPD offers innovative ways to study polyaminopathies, associated disabilities and develop strategies for treatment and prevention. This collaborative effort between Spectrum Health and Michigan State University brings world leading experts in the field from the bench and clinic together to study these rare genetic diseases.
The ICPD is led by:
Before the discovery of the Bachmann-Bupp Syndrome, there was one other known polyamine disorder, Snyder-Robinson Syndrome (SRS). This condition results from mutations in the spermine synthase gene (SMS) and was first discovered in 2003. It also results in abnormalities of polyamine levels. There are now approximately 65 males with SRS worldwide. The ICPD will serve as a center for clinical evaluation and research for SRS.
There are also two other newer conditions in the polyamine pathway (pending publication). There are at least 20 potential conditions in the polyamine pathway and all would fall under the umbrella of the ICPD scope of work.
The ICPD is headquartered in Grand Rapids, Michigan and serves as the worldwide nexus for comprehensive data/sample collection and scientific information about polyamine-associated diseases. ICPD has strong ties and collaborates with the Greenwood Genetic Center in South Carolina and the Snyder-Robinson Foundation.
- Bupp CP, Schultz CR, Uhl KL, Rajasekaran S, Bachmann AS. Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features. Am J Med Genet A. 2018;176(12):2548-2553. PMID: 30239107
- Bachmann AS, Geerts D. Polyamine Synthesis as a target of MYC oncogenes. J Biol Chem. 2018;293(48):18757-18769. PMID: 30404920
- Schultz CR, Bupp CP, Rajasekaran S, Bachmann AS. Biochemical features of primary cells from a pediatric patient with a gain-of-function ODC1 genetic mutation. Biochem J. 2019;476(14):2047-2057. PMID: 31249027
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