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Huntington’s Disease (HD) is an inherited progressive neurodegenerative disorder characterized by choreiform movements, psychiatric problems, and dementia. It is caused by a cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin (HTT) gene on chromosome 4p and inherited in an autosomal-dominant pattern.

Mild Cognitive Impairment (MCI) is a syndrome between the cognitive changes of aging and dementia. MCI refers to a condition in which there is a decline in your usual cognitive abilities, such as memory, language functions and reasoning. But, it not to the extent that it alters daily activities of living, like banking, driving, managing medications and taking care of usual responsibilities. It's a cognitive impairment that doesn't meet the criteria for dementia. Several criteria and subtypes of MCI have been proposed. In general, criteria includes a measurable deficit in cognition in at least one domain, in the absence of dementia or impairment in activities of daily living.

Cortical Basal Degeneration (CBD) is a rare progressive neurodegenerative disorder characterized by cognitive or behavioral abnormalities, and development of asymmetric movements characterized by various combinations of akinesia, rigidity, dystonia, focal myoclonus, ideomotor apraxia, and alien-limb phenomena. A wider range of clinical presentations is increasingly apparent.