Neuromuscular  Research


Dietary modifications and effect on Myasthenia Gravis
The purpose of this research is to investigate a possible holistic regimen to managing myasthenia gravis. The current therapies are effective in managing myasthenia gravis; however, the intention of this research is to investigate changes in diet leading to adjunctive management of the disease. If there is improvement in symptoms with dietary changes this could potentially reduce the dose of treatment medications. Smaller doses of medications leads to less side effects and therefore a better quality of life in patients with myasthenia gravis. 

Myasthenia gravis is a chronic autoimmune neuromuscular disease; therefore, if patients consume a diet, which can decrease inflammation and mitigate their immune system, it could have an effect on their immune system and an effect on their disease process. We are interested in investigating your recent dietary changes and disease symptoms associated with those changes in your diet.
 
Clinical Investigator:  Twydell, Paul

Contact: 
Brandon James
Brandon.James@spectrumhealth.org
616.486.2058

We currently have no other research studies within neuromuscular medicine.  Please check back later.  

 


Below is a list of publications and posters presentations from previous studies and cases:

Current treatment practice of Guillain-Barré syndrome. Verboon C, Doets AY, Galassi G, Davidson A, Waheed W, Péréon Y, Shahrizaila N, Kusunoki S, Lehmann HC, Harbo T, Monges S, Van den Bergh P, Willison HJ, Cornblath DR, Jacobs BC; IGOS Consortium. Neurology. 2019 Jul 2;93(1):e59-e76. doi: 10.1212/WNL.0000000000007719. Epub 2019 Jun 7. 

Regional variation of Guillain-Barré syndrome. Doets AY, Verboon C, van den Berg B, Harbo T, Cornblath DR, Willison HJ, Islam Z, Attarian S, Barroso FA, Bateman K, Benedetti L, van den Bergh P, Casasnovas C, Cavaletti G, Chavada G, Claeys KG, Dardiotis E, Davidson A, van Doorn PA, Feasby TE, Galassi G, Gorson KC, Hartung HP, Hsieh ST, Hughes RAC, Illa I, Islam B, Kusunoki S, Kuwabara S, Lehmann HC, Miller JAL, Mohammad QD, Monges S, Nobile Orazio E, Pardo J, Pereon Y, Rinaldi S, Querol L, Reddel SW, Reisin RC, Shahrizaila N, Sindrup SH, Waqar W, Jacobs BC; IGOS Consortium. Brain. 2018 Oct 1;141(10):2866-2877. doi: 10.1093/brain/awy232.

Twydell, PT. Lumbosacral Plexus Syndromes. In:  “UpToDate” (Rose, BD,Ed.); UpToDate, Waltham, MA. (current, revised yearly) Hamdallah, A; Shaker, H; Atanga, P; Twydell, P.  Novel mutation in gene KCNA1 in a patient with episodic ataxia Type I. 2018 AAN Annual Meeting Poster Presentation. Presented by Dr.’s Atanga & Twydell.

Simmons, D; Villanueva, R; Twydell, P; Logigian, EL. The Long Exercise Test in Primary Periodic Paralysis: a Bayesian Analysis. 2018 AAN Annual Meeting Poster Presentation. Presented by Dr. Simmons.

Barohn, RJ; Gajewski, B; PAIN-CONTROLS Study Group. Patient Assisted Intervention for Neuropathy: Comparison of treatment in real life situations (PAIN-CONTRoLS). 2018 AAN Annual Meeting Poster Presentation.

Hamdallah, A; Shaker, H; Atanga, P; Twydell, P. Novel mutation in gene KCNA1 in a patient with episodic ataxia Type I. Grand Rapids Citywide Research Day 2018.

Mundwiler A and Shakkottai VG. Autosomal-dominant cerebellar ataxias. In: Handbook of Clinical Neurology. 2018;147:173-185.

Jacobs BC, van den Berg B, IGOS Consortium, et al. International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome. J Peripher Nerv Syst. 2017. June; 22(2):68-76.

Jacobs, BC, Vanden Berg, B, Verboon, C, et al; IGOS Consortium. International Guillain-Barré Syndrome Outcome Study (IGOS): Protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome. J Peripher Nerv Syst. 2017 Apr 12.

Hamdallah A, Li Y, Twydell P. Radiological “snake eyes” sign due to anterior epidural spinal cyst mimicking Hirayama’s disease. 2017 AAN poster presentation.

London ZN, Mundwiler A, Oral H, Gallagher GW. Nerve conduction studies are safe in patients with central venous catheters. Muscle Nerve. 2017;56(2):321-323.

Logigian EL, Villanueva R, Twydell PT, et al.  Electrodiagnosis of ulnar neuropathy at the elbow (Une): a Bayesian approach. Muscle Nerve. 2014 Mar; 49(3): 337-44.

Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS) Sponsor: University of Kansas Medical Center

Compassionate Distribution Treatment Protocol: Treatment of Lambert-Eaton Syndrome with 3,4-Diaminopyridine

IGOS - A prospective INC study on clinical and biological predictors of disease course and outcome in Guillain-Barré Syndrome (GBS)