Our Molecular Diagnostics Lab

Spectrum Health Molecular Diagnostics Laboratory provides nucleic-acid-based diagnostics and advanced genetic testing. Performing more than 35,000 tests annually, the laboratory is one of three Spectrum Health specialty facilities that bring state-of-the-art diagnostic laboratory testing to the region. 


Our services incorporate automated robotic specimen processing and advanced software applications to ensure the quality and accuracy of our diagnostics. We offer many molecular assays, such as: 
  • Molecular biomarkers for cancer treatment
  • Factor V Leiden (F5), prothrombin (F2), and methylenetetrahydrofolate hypercoagulation risk factors
  • Hemochromatosis HFE genotyping for iron overload 
  • Cystic fibrosis carrier screening
  • Minimal residual disease monitoring (BCR/ABL1)
  • Women’s health (HPV, CT/GC, trichomoniasis)
  • Lynch syndrome screening (MSI, MLH1 methylation, BRAF)
  • Quantitative viral load (CMV, EBV, adenovirus, HCV, HBV)
  • Viral genotyping (HPV16/18/45, HCV)
  • Epi ProColon blood test for colon cancer screening

Coming Soon

  • Panorama NIPT

In addition, we support our infectious disease doctors with ultrasensitive PCR detection of HSV1/2 on CSF and plasma specimens. We also provide post-transplant engraftment monitoring testing for both pediatric and adult bone marrow transplant programs. 

Our laboratory is embracing the field of personalized cancer treatment and updates our site-specific cancer mutation panels (e.g., lung cancer, colon cancer, glioma and hematologic malignancies) on a regular basis in response to the current NCCN guidelines. 


Our tests are based on the latest research and are performed on the most sophisticated platforms available to the clinical laboratory. The laboratory actively participates in clinical trials and has gained early access to next-generation technologies. 

Testing platforms range from simple to state of the art, including: 

  • Restriction fragment-length polymorphism 
  • Polymerase chain reaction (PCR) amplification 
  • RT-PCR
  • Fluorescent short tandem repeat analysis
  • Methylation analysis
  • Automated capillary gene sequencing
  • Invader™
  • Hologic Panther
  • Abbott m2000
  • Ion Torrent PGM
  • Illumina MiSeq
  • Pyrosequencing

Comprehensive Test Menu

  • Inherited genetic disorders
  • Hematologic and oncologic testing
  • Minimal residual disease monitoring
  • Infectious diseases

Analyses are typically performed on DNA or RNA isolated from:

  • Peripheral blood
  • Bone marrow
  • Biopsy tissue
  • Urine
  • Spinal fluid
  • Cultured cells
  • Fixed tissues
  • ThinPrep PreservCyt
  • cf DNA