Cancer Health

Cancer Clinical Trials


Condition Description Investigator  Contact Information 

Blood & Bone Marrow Transplant

 NK Cells: Analysis of Natural Killer Cells in Hematopoietic Stem Cell Transplant Patients and Donors

Natural killer (NK) cells are a type of white blood cell that play an important role in fighting against viral infections. This study collects blood from the donor and the recipient of a hematopoietic stem cell transplant (HSCT) to look at the affect on NK Cells and the ability to fight against a range of viral infections. 
Williams, Stephanie
Laura Paulsen 

Blood & Bone Marrow Transplant

REACH1: A Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease 

This study will help us better understand if taking ruxolitinib (the study drug) in combination with corticosteroids is safe and effective in people who have acute graft versus host disease (GVHD) a stem cell transplant.

For more information, click here.

Abidi, Muneer, H.
 
Laura Paulsen 
Blood & Bone Marrow Transplant
BMT Cord Blood Access Protocol: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) in Pediatric and Adult Patients with Hematologic Malignancies and other Indications

This is an access study in which umbilical cord blood used for bone marrow transplant is only available through this access and distribution study. In October 2011, the Food and Drug Administration (FDA) began considering cord blood as a biological drug. In the United States, drugs must meet standards set by the FDA to make sure they are safe. Cord blood units that were not collected, tested, or stored exactly according to FDA standards may be used for transplant if the transplant is done as part of a study. 

For more information, click here.

Abdel-Mageed, Aly 
Laura Paulsen 
Blood & Bone Marrow Transplant
NYBB UCB: A multicenter safety study of unlicensed, investigational cryopreserved cord blood units (CBUs) manufactured by the National Cord Blood Program (NCBP) and provided for unrelated hematopoietic stem cell transplantation of pediatric and adult patients

Umbilical cord blood used for bone marrow transplant which is only available through this access and distribution study. In October 2011, the Food and Drug Administration (FDA) began considering cord blood as a biological drug. In the United States, drugs must meet standards set by the FDA to make sure they are safe. Cord blood units that were not collected, tested, or stored exactly according to FDA standards may be used for transplant if the transplant is done as part of a study.
Abdel-Mageed, Aly 
Laura Paulsen 
Blood & Bone Marrow Transplant
Multiple Cord Blood: Allogeneic Stem Cell Transplantation Using Multiple Unrelated Donor Umbilical Cord Grafts

This research study will evaluate the ability of umbilical cord blood cells, which have been obtained from multiple unrelated donors, to serve as a source of stem cells for patients undergoing stem cell transplant. The use of a single unrelated umbilical cord blood unit is common for small pediatric patients requiring stem cell transplantation when a related or unrelated donor is not available. For larger patients, the use of more than one umbilical cord blood unit provides an adequate number of stem cells and increases the chances of successful engraftment and survival.
Abdel-Mageed, Aly 
 
Laura Paulsen 
Blood & Bone Marrow Transplant 
Brincidofovir: Expanded Access Protocol to Provide Brincidofovir for the Treatment of Serious Adenovirus Infection or Disease

This study is an access protocol to provide treatment of the investigational drug called brincidofovir (BCV) to treat the virus called adenovirus (AdV).

For more information, click here.

Duffner, Ulrich
Laura Paulsen
Brain-CN (Neurology)
2016-034: Glimoa Data Registry for Research

The purpose of this research is to establish an ongoing data collection registry, where a wealth of information provided by patients with gliomas can help future researchers evaluate the practice patterns, as well as pathological and clinical outcomes associated with the treatment of gliomas. 
Sherman, Wendy
Eric Laney 
 Brain-CN (Neurology)  Brain-CN (Neurology) trials offered through Cancer Research Consortium of West Michigan.    
Breast
M12-914: A phase III randomized, placebo-controlled trial of carboplatin and paclitaxel +/- the PARP inhibitor, veliparib (ABT-888) in HER-2-negative metastatic or locally advanced unresectable BRCA-associated breast cancer

The purpose of this study is to determine the effectiveness of veliparib in the treatment of locally advanced (spread to nearby tissue) or metastatic (spread to other parts of your body) HER 2-negative breast cancer and have been confirmed or highly suspected BRCA1 or BRCA2 mutation.  Secondarily, we will look at how the drug is absorbed, broken down and removed from your body; and look for biomarkers or early signs that the study drug is working. 

For more information, click here.

Melnik, Marianne 
Mollie Lockard
Breast 
PVB vs PNB: Paraverteberal Block Versus Pectoral Nerve Block for Analgesia Following Mastectomy

The purpose of this study is to compare two standard methods of pain control management used at Spectrum Health for patients undergoing breast surgery. 
Melnik, Marianne

Marianne Morissey 
cancer.research@spectrumhealth.org
616.486.8500

Breast
SOLAR 1: A phase III randomized double-blind, placebo controlled study of alpelisib in combination with fulvestrant for men and postmenopausal women with hormone receptor positive, HER 2-negative advanced breast cancer which progressed on or after aromatase inhibitor treatment 

The purpose for the study is to learn whether alpelisib, when added to a marketed standard treatment (fulvestrant), helps to reduce the growth of breast cancer cells in people with hormone receptor-positive, HER 2-negative advanced breast cancer.

For more information, click here.

Melnik, Marianne 
Mollie Lockard
Breast Breast cancer trials offered through Cancer Research Consortium of West Michigan.    
Colorectal  Colorectal trials offered through Cancer Research Consortium of West Michigan    
Genitourinary
CaPSURE: Cancer of the Prostate Strategic Urologic Research Endeavor Tissue Consent

This study is to determine the impact of prostate cancer on a patient’s well-being, study the use of tests and treatment in the care of prostate cancer, and help guide research towards better treatments. 
 Lane, Brian
Sue Engerman

Genitourinary 
ARAMIS: A multinational, randomized, double-blind, placebo-controlled, Phase III efficacy and safety study of ODM-201 in men with high-risk non-metastatic castration-resistant prostate cancer

This study is for men who have been on ADT for their recurrent prostate cancer and their PSA continues to rise without evidence of metastasis on imaging. The study drug  is an androgen deprivation therapy that deprives the cancer cells of testosterone needed for cancer growth.

For more information, click here.

Brede, Christopher 
Sue Engerman
Genitourinary
The Bladder Irrigation Comparison (BIC) Study: a Prospective, Open-Label Randomized Clinical Trial of a Single Bladder Instillationof Mitomycin C vs. Gemcitabine vs. No Additional Treatment Immediately after Transurethral Resection of Bladder Tumor

This study is comparing three standard treatments post removal of a bladder tumor in surgery. Physicians are trying to learn which of these standard treatments provides the chance of preventing tumor recurrence with the least amount of side effects.

For more information, click here.

Humphrey, John
Sue Engerman
Genitourinary 
G Minor: Genomics in Michigan Impacting Observation or Radiation

The G-Minor study is for men who have had a radical prostatectomy with high risk factors on their pathology. We  are comparing two tests (the Capra-S Nomogram  and the  Decipher® Test)  to see how they affect the patient and physician's decisions regarding receiving additional treatment after surgery. The tests give a percent chance of the prostate cancer recurring or spreading in the future. 

For more information, click here.

Lane, Brian 
Sue Engerman
Genitourinary
INSTILADRIN: A Phase III, Open Label study to Evaluate the Safety and Efficacy of INSTILADRIN (rAd-IFN/Syn3) Adminstered Intravesically to Patients with High Grade, BCG Unresponsive Non-Muscle Invasive Bladder Cancer

This study if for patients who have high grade non-invasive bladder cancer T1, Ta or CIS and whose cancer has recurred despite receipt of BCG therapy. The study drug is an immunotherapy which helps the patients own body to fight the cancer cells. 

For more information, click here.

Lane, Brian
Sue Engerman
Genitourinary  Genitourinary (GU) trials offered through Cancer Research Consortium of West Michigan.      
Gynecologic  Gynecologic trials offered through Cancer Research Consortium of West Michigan.     
Head & Neck  Head & Neck trials offered through Cancer Research Consortium of West Michigan    
Leukemia  Leukemia trials offered through Cancer Research Consortium of West Michigan    
Lung  Lung trials offered through Cancer Research Consortium of West Michigan    
Lymphoma  Lymphoma trials offered through Cancer Research Consortium of West Michigan    
Melanoma  Melanoma trials offered through Cancer Research Consortium of West Michigan    
Mulitsite  Multisite trials offered through Cancer Research Consortium of West Michigan.
   
Myeloma  Myeloma trials offered through Cancer Research Consortium of West Michigan    
Sarcoma 
MSTA: Musculoskeletal Tumor Tissue Acquisition Protocol

This study will collect biospecimens and medical information for use in laboratory research to learn more about bone tumors and musculoskeletal diseases. Future research is focused on the prevention, diagnosis and treatment. 
Steensma, Matthew 
Heidi DeVries
Sarcoma
Genetic Outlier: The Identification of Novel Mutations in Outlier Patients

This study is to better understand more about germline mutations (hereditary mutations) in those that have unique circumstances surrounding their medical condition or the medical condition of a family member. Researchers are looking to develop a mechanism for discovery-level genetic research in individuals who have characteristics of a genetic disease or syndrome which cannot currently be linked to a known germline mutation.  Participation is by invitation only.
Steensma, Matthew 
Heidi DeVries
Sarcoma
Femoral Met Repair: A prospective, randomized surgical trial comparing postoperative functional outcomes among cancer patients treated with long-stem cemented hemiarthroplasty (LSCH) verses intramedullary nail (IMN) for pathologic subtrochanteric femur fractures

This study is being done to look at two different types of surgeries routinely used for treating metastases, the spread of cancer in the upper portion of the femur.
Steensma, Matthew  
Heidi DeVries
Sarcoma  Sarcoma trials offered through Cancer Research Consortium of West Michigan    
Unknown Primary  Unknown Primary trials offered through Cancer Research Consortium of West Michigan    
Upper Gastrointestinal  TXA: Evaluating the effect of Tranexamic Acid on blood lost and transfusion rates in major oncologic surgeries

This study looks at the use of tranexamic acid in hopes that it will decrease bleeding related to major surgery, resulting in reduced blood loss, lower blood transfusion rates, and possibly decreased hospital costs related to your surgical hospital stay. 
Chung, Mathew 
Eric Laney 
Upper Gastrointestinal  Upper Gastrointestinal (UGI) trials offered by Cancer Research Consortium of West Michigan    

For other clinical trials available for cancer health, visit Cancer Consortium of West Michigan at: www.crcwm.org. You can also visit clinicaltrials.gov for opportunities internationally.